Internal / External CFD / Pipeflo / Short Break Analysis, Buffer Vessel Sizing.
Each product and portfolio and company is different.What I find interesting.
how production unit scale in some circumstances could have very significant impacts on financial returns.over the lifetime of a portfolio of products.and where there appears to be little impact..
It is also worth saying that the results have not been modelled where there are lower risk profiles than those of bringing new pharmaceutical products to market.. Let me start with a first curve.. M. odelled.a scenario where the revenue value of the new products was very high.
you can see that scale has little relative influence over the NPV at different scales.
There is a difference, smaller scale has a lower return and somewhere the scale can be optimised, but changes are relatively small and would suggest that sticking with an installed or familiar scale may make sense, if you are confident that most of your products will be blockbusters..We want to remove anything which doesn’t add value.
To achieve the best possible results, we must change the way we think, the way we manage materials and people.Design must form the entry point, with that particular element of P-DfMA serving as the foundation and pervading principle for everything which follows.
We must allow the manufacture and assembly process to drive the way we design the asset in the first place, as well as the way we engage the client and the supply chain..Integrated design.